Substance name: Spinosad. spinosad topical. Chemical formula: C83H132N2O20Drugbank ID: DB08823. [5] Two other uses for spinosad are for pets and humans. There are two patents protecting this drug. We comply with the HONcode standard for trustworthy health information -, Search the entire Drugs.com site for spinosad. [4] Spinosyn A is highly active against neonate larvae of the tobacco budworm, Heliothis virescens, and is slightly more biologically active than spinosyn D. In general, spinosyns possessing a methyl group at C6 (spinosyn D-related analogs) tend to be more active and less affected by changes in the rest of the molecule. Trade Name: Antixx Liquid Ant Bait Active Ingredient: Spinosad Supplier Info: W. Neudorff GmbH KG An der Muhle 3 Emmerthal 31860 Germany Office 250-652-5888 Labels: Natroba is a drug marketed by Parapro Llc and is included in one NDA. How the information is presented. [16], InChI=1S/C42H67NO10.C41H65NO10/c1-11-26-13-12-14-35(53-37-16-15-34(43(6)7)24(4)49-37)23(3)38(45)33-20-31-29(32(33)21-36(44)51-26)17-22(2)28-18-27(19-30(28)31)52-42-41(48-10)40(47-9)39(46-8)25(5)50-42;1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h17,20,23-32,34-35,37,39-42H,11-16,18-19,21H2,1-10H3;14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3/t23-,24-,25+,26+,27-,28+,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+;22-,23-,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,36+,38+,39-,40-,41+/m11/s1, (A): InChI=1/C42H67NO10.C41H65NO10/c1-11-26-13-12-14-35(53-37-16-15-34(43(6)7)24(4)49-37)23(3)38(45)33-20-31-29(32(33)21-36(44)51-26)17-22(2)28-18-27(19-30(28)31)52-42-41(48-10)40(47-9)39(46-8)25(5)50-42;1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h17,20,23-32,34-35,37,39-42H,11-16,18-19,21H2,1-10H3;14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3/t23-,24-,25+,26+,27-,28+,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+;22-,23-,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,36+,38+,39-,40-,41+/m11/s1, Except where otherwise noted, data are given for materials in their, The non‐target impact of spinosyns on beneficial arthropods, Spinosad toxicity to pollinators and associated risk, "Saccharopolyspora spinosa sp. Spinosad is an insecticide based on chemical compounds found in the bacterial species Saccharopolyspora spinosa. Tradename (spinosad) Suspension, 0.9% was demonstrated to be statistically superior to an active comparator NIX (permethrin 1%) in each of two well-controlled pivotal, Phase 3 trials. [5] The mode of action of spinosoid insecticides is by a neural mechanism. It is considered a natural product, thus is approved for use in organic agriculture by numerous nations. Spinosad is a mixture of spinosyn A and spinosyn D. Chemical name ... Trade names: Success, Tracer, Spintor, Spinoace, Boomerang, Laser, Extinosad Structural formula: Spinosyn A O O O O O H H H H H CH 3 O CH 3 O CH CH 3O 3 OCH 3 CH 3 2 (CH 3) 2N OCH 3. [1], Spinosad is highly active, by both contact and ingestion, in numerous insect species. It is a mixture of two chemicals called spinosyn A and spinosyn D. It is used to control a wide variety of pests. … TRACER is an suspension concentrate formulation with 480 g ai.L-1, while LASER is an aqueous suspension emulsion in oil with 125 g ai.L-1. S.No. Spinosad topical suspension, 0.9%, was approved by the U.S. Food and Drug Administration (FDA) on 2011-01-18 for the topical treatment of head lice infestation in patients four (4) years of age and older. BAS number: 49 . Ecotoxicology parameters have been reported for spinosad, and are:[14], Chronic exposure studies failed to induce tumor formation in rats and mice; mice given up to 51 mg/kg/day for 18 months resulted in no tumor formation. SPINOSAD (203) IDENTITY ... ISO common name: spinosad. Min.Order: 1 Kilogram FOB Price: USD $ 1.0-3.0/Kilogram hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm Pyriproxyfen has low acute toxicity. Conserve SC Spinosad/spintor Spinosyn A and Spinosyn D 5 Dow AgroSciences Coragen Chlorantraniliprole 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide 28 Dupont Co-Ral Coumaphos O,O-diethyl O-(3-chloro-4-methyl-2-oxo2H-1-enzopyuran 7-yl- phosphorothioate 1B Bayer Corporation [8] It was first registered as a pesticide in the United States for use on crops in 1997. Known as a developmental or reproductive toxin in humans, this chemical is highly toxic to aquatic life. NDC Product Information Natroba with NDC 52246-929 is a a human prescription drug product labeled by Parapro Llc. It affects certain species only in the adult stage, but can affect other species at more than one life stage. The genus Saccharopolyspora was discovered in 1985 in isolates from crushed sugarcane. Forosamine at the 17-position of spinosyns A and D was hydrolyzed under mild acidic conditions to give the corresponding 17-pseudoaglycones. Spinosad was obtained from Dow Agro Sciences (Indianapolis, IN), and the pyrethrins was from McLaughlin Gormley King (Minneapolis, MN). Natroba is sold for treatment of human head lice. The results table presents information on an active substance, such as approval start and end date, evaluating competent authority and approval or assessment status. [5] It is regarded as natural product-based, and approved for use in organic agriculture by numerous national and international certifications. Spinosad(Natroba) generic is a pediculicide (a topical suspension), prescribed for head lice. Common, Chemical and Trade Names of Insecticides Used in this Guide Trade Common Name Chemical Name IRAC Classification Company Abate Temephos O,O -(thiodi-4,1-phenylene) O,O, O' O'-tetramethyl phosphorothioate 1B BASF Corporation Abba Abamectin a mixture of avermectin B1a (10E,14E,16E,22Z)- 2 Spinosad is an aerobic fermentation product of the soil bacterium, ... 32 Chemical Names: The name spinosad is derived from 33 combining the characters from spinosyn A and spinosyn 34 D. The material is a mixture of about 85% Spinosyn A ... 51 Trade Names: Tracer, Success, Conserve, Spintor. Suspension, External: Natroba: 0.9% (120 mL) [contains benzyl alcohol, cetearyl alcohol, fd&c yellow #6 (sunset yellow), isopropyl alcohol, propylene glycol] Generic: 0.9% (120 mL) Spinosoid binding leads to disruption of acetylcholine neurotransmission. [7], Spinosad has been used around the world for the control of a variety of insect pests, including Lepidoptera, Diptera, Thysanoptera, Coleoptera, Orthoptera, and Hymenoptera, and many others. Spinosad controls a wide variety of pests including fleas, caterpillars, fruit flies, spider mites, fire ants, leaf beetle larvae, thrips, leaf miners and leaf beetle larvae to name only a few.It is recommended as one component of Integrated Pest Management for greenhouses because it does not target beneficial insects such as ladybugs and predatory mites. Several spinosad formulations under the trade name Natular, ranging from fast release emulsifiable concentrate and granules to slow release tablets and briquets, have been registered for mosquito control in the United States and elsewhere (Clarke, Roselle, IL). Active Substance details. It is used to control a wide variety of pests. [2] Spinosad so far has proven not to cause cross-resistance to any other known insecticide. It is marketed as the trade name Natroba in the US by ParaPRO Pharmaceuticals. nov. Isolated from soil Collected in a Sugar Mill Rum Still", 10.1002/1526-4998(200102)57:2<177::AID-PS281>3.0.CO;2-Z, "Spinosad: A new natural product for stored grain protection", "Resistance and cross-resistance to the spinosyns- A review and analysis", "Safer Flea Control | Insects in the City", "Codling Moth and Leafroller Control Using Chemicals", "Spinosad Insecticide: Subchronic and Chronic Toxicity and Lack of Carcinogenicity in CD-1 Mice", "Spinosad Insecticide: Subchronic and Chronic Toxicity and Lack of Carcinogenicity in Fischer 344 Rats", https://en.wikipedia.org/w/index.php?title=Spinosad&oldid=998542987, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with multiple CAS registry numbers, Chemical articles with multiple PubChem CIDs, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Wikipedia articles needing clarification from June 2014, Creative Commons Attribution-ShareAlike License, This page was last edited on 5 January 2021, at 21:34. Class : Common Name : Trade Name-----I piperonyl butoxide Butacide, Incite I potassium salts Safer Insecticidal Soap F potassium bicarbonate Kaligreen Look for spinosad under the following trade names: Monterey Garden Insect SprayR, Ferti-lomeR Borer, Bagworm, Leafminer & Tent Caterpillar Spray, and Bulls-EyeTM Bioinsecticide. Its labeled use rate is set at 1 ppm (1 mg a.i./kg of grain) and its maximum residue limit (MRL) or tolerance is set at 1.5 ppm. This product is available in EC(Emulsifiable Concentrate),SC(Suspension Concentrate) form. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Spinosad is a metabolite produced by fermentation of the naturally occurring soil bacteria Saccharopolyspora spinosa. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. [9][10] Trifexis also includes milbemycin oxime. Spinosad has recently been used in oral preparations (as Comfortis) to treat C. felis, the cat flea, in canines and felines; the optimal dose set for canines is reported to be 30 mg/kg. Brand names: NatrobaDrug class(es): topical anti-infectivesSpinosad topical is used in the treatment of: → Search the entire Drugs.com site for spinosad. Tracer is comprised primarily of two macrocyclic lactones, Spinosyn A and D, secondary metabolites produced by the actinomycete, Saccharopolyspra spinosa under natural fermentation condition. Spinosad, comprising spinosyn A and spinosyn D in a ratio of approximately 85:15, is the active ingredient in the formulations TRACER and LASER. [7] The apparent lack of spinosyn A metabolism may contribute to its high level of activity, and may compensate for the slow rate of penetration. [15] Similarly, administration of 25 mg/kg/day to rats for 24 months did not result in tumor formation. Trade name: BOITES ANTI-FOURMIS. Spinosad 0.9% topical suspension is used to treat head lice infestations. US Brand Name. Information about pesticides used in urban situations. Toxicity in mammals. [8] Spinosad residues are highly stable on grains stored in bins, with protection ranging from 6 months to 2 years. Seduce OG (spinosad): An insecticidal bait derived from the soil bacterium Saccharopolyspora spinosa; acts as a nerve and stomach poison. Attracts and kills insects feeding on or near the base of plants. However, these conditions led to decomposition of the 17-pseudoaglycone of … [2] Spinosad also has secondary effects as a γ-amino-butyric acid (GABA) neurotransmitter agonist. Spinosad is a natural substance made by a soil bacterium that can be toxic to insects. These include thrips, leafminers, spider mites, mosquitoes, ants, fruit flies and others.Many products containing spinosad are used on crops and ornamental plants. - Related authorised biocidal products (trade name of a biocidal product). 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