creatine monohydrate side effects

Endocrine 2014;45(3):354-61. View abstract. Is running performance enhanced with creatine serum ingestion? Int J Chron.Obstruct.Pulmon.Dis 2006;1(4):445-453. Alves, C. R., Ferreira, J. C., de Siqueira-Filho, M. A., Carvalho, C. R., Lancha, A. H., Jr., and Gualano, B. Creatine-induced glucose uptake in type 2 diabetes: a role for AMPK-alpha? Klivenyi P, Ferrante RJ, Matthews RT, et al. Bassit, R. A., Curi, R., and Costa Rosa, L. F. Creatine supplementation reduces plasma levels of pro-inflammatory cytokines and PGE2 after a half-ironman competition. Rossouw F, Kruger PE, Rossouw J. Hultman E, Soderlund K, Timmons JA, et al. Alves CR, Santiago BM, Lima FR, et al. View abstract. View abstract. J R.Army Med Corps 2010;156(1):41-43. J Strength.Cond.Res 2003;17(3):421-424. View abstract. J Appl Physiol 1997;83:2055-63. View abstract. Med.Sci.Sports Exerc. Vasc.Med. Kingsley, M., Cunningham, D., Mason, L., Kilduff, L. P., and McEneny, J. Vandenberghe K, Van Hecke P, Van Leemputte M, et al. Early research shows that taking creatine daily for 8 weeks enhances the effects of the antidepressant drug escitalopram in women with major depressive disorder. Sports Med 1999;27(2):97-110. Persky AM, Muller M, Derendorf H, et al. A. Absorption of creatine supplied as a drink, in meat or in solid form. Myburgh, K H FACSM, Bold, A*, Bellinger, B*, Wilson, G*, and Noakes, T D FACSM. The New York Times. View abstract. J Med Food 2014;17(9):1022-6. Walter, M. C., Reilich, P., Lochmuller, H., Kohnen, R., Schlotter, B., Hautmann, H., Dunkl, E., Pongratz, D., and Muller-Felber, W. Creatine monohydrate in myotonic dystrophy: a double-blind, placebo-controlled clinical study. J Strength.Cond.Res 2004;18(2):272-275. Int J Sports Med 2000;21:139-45. Eur J Appl Physiol Occup Physiol 1999;80:165-8. 2009;1173:829-836. Cochrane.Database.Syst.Rev. Lugaresi, R., Leme, M., de, Salles Painelli, V, Murai, I. H., Roschel, H., Sapienza, M. T., Lancha Junior, A. H., and Gualano, B. This is simply not the case. J Appl Physiol 1999;87:2244-52. Res Sports Med 2014;22(1):61-74. View abstract. View abstract. Eur.J Appl.Physiol Occup.Physiol 1998;78(1):83-92. Aust.J Sci.Med Sport 1997;29(3):65-68. NCAA prohibits schools from supplying creatine to students. View abstract. Watsford, M. L., Murphy, A. J., Spinks, W. L., and Walshe, A. D. Creatine supplementation and its effect on musculotendinous stiffness and performance. View abstract. WebMD does not provide medical advice, diagnosis or treatment. View abstract. View abstract. FEBS Lett 11-20-1998;439(3):357-362. Carbohydrate ingestion augments creatine retention during creatine feeding in humans. 2011 May;40(5):1409-18. doi: 10.1007/s00726-011-0878-2. Effect of creatine supplementation on metabolism and performance in humans during intermittent sprint cycling. View abstract. Matsumura, T., Yokoe, M., Nakamori, M., Hattori, N., Saito, T., Nozaki, S., Fujimura, H., and Shinno, S. [A clinical trial of creatine monohydrate in muscular dystrophy patients]. J Clin Pharmacol 2003;43:29-37. . 1997 Jun;7(2):138-43 J Virol 1995;69:4656-7. Caffeine and progression of Parkinson Disease: a deleterious interaction with creatine. View abstract. Nausea 3. Med Sci.Sports Exerc. Bennett, T., Bathalon, G., Armstrong, D., III, Martin, B., Coll, R., Beck, R., Barkdull, T., O'Brien, K., and Deuster, P. A. Ziegenfuss T, Lowery LM, and Lemon PW. The reason for this is that intake of creatine draws water into the muscles and that reflects as an increase in weight. 2016 Jun;30(6):1763-6. Side Effects of Creatine In appropriate doses, creatine is generally safe to take. J Int Soc Sports Nutr. View abstract. 8-1-2008;178(3):233-239. Arg Bras Cardiol 2012;99:623-9. View abstract. View abstract. Delecluse, C., Diels, R., and Goris, M. Effect of creatine supplementation on intermittent sprint running performance in highly trained athletes. View abstract. View abstract. Ling, J., Kritikos, M., and Tiplady, B. Cognitive effects of creatine ethyl ester supplementation. Chorney JA, Cohen J. Pigmented purpuric dermatosis associated with creatine supplementation (letter). Clin Chim.Acta 2001;308(1-2):173-178. Creatine supplementation and swimming performance. Juhasz, I., Gyore, I., Csende, Z., Racz, L., and Tihanyi, J. Creatine supplementation improves the anaerobic performance of elite junior fin swimmers. Effect of high-dose creatine therapy on symptoms of exercise intolerance in McArdle disease: Double-blind, placebo-controlled crossover study. The effect of oral creatine supplementation on the 1000-m performance of competitive rowers. Effects of oral creatine supplementation on multiple sprint cycle performance. Creatine ruled out in athletes' deaths. View abstract. View abstract. Neurology 2003;60:500-2.. View abstract. Arch Intern Med 6-11-2001;161(11):1455-1456. View abstract. Jäger R, Purpura M, Shao A, Inoue T, Kreider RB. Birch R, Noble D, Greenhaff PL. Osteoarthritis. View abstract. 2016 Oct;83:112-9. J.Sports Med.Phys.Fitness 2006;46(4):555-563. Anesth.Analg. Fatal rhabdomyolysis with bilateral gluteal, thigh, and leg compartment syndrome after the Army Physical Fitness Test. -, Int J Sport Nutr. Taking the stimulants caffeine and ephedra with creatine can increase the risk of side effects. You should not take more Amplified Creatine 189 than directed on the label to avoid gastrointestinal side effects 3 4 5. J Appl.Physiol 1999;86(3):840-844. Accessed March 12, 2017. Effects of oral creatine and resistance training on myosin heavy chain expression. No, studies have shown that consumption of creatine monohydrate does not cause any serious adverse side effects. Magn Reson.Med. Francaux M, Demeure R, Goudemant JF, Poortmans JR. Effect of exogenous creatine supplementation on muscle PCr metabolism. Taking lower doses of creatine daily for 6 months does not improve exercise capacity or heart failure symptoms in men. But creatine does not seem to improve aerobic exercise capacity, pain, sleep, quality of life, or mental function in people with fibromyalgia. 2009;66(9):1099-1104. View abstract. View abstract. Early research on the use of creatine by mouth in people with muscular dystrophy is not clear. Neurorehabil Neural Repair 2007;21:107-15. View abstract. Br J Sports Med 2006;40(6):507-511. Cochrane.Database.Syst.Rev. J Strength.Cond.Res 2002;16(1):109-116. Gordon A, Hultman E, Kaijser L, et al. 2009;23(3):818-826. (check all that apply). View abstract. Creatine Monohydrate Side Effects For years the media has portrayed creatine as a dangerous, poorly understood supplement and that long-term use may result in bad health outcomes. View abstract. Sijens, P. E., Verbruggen, K. T., Meiners, L. C., Soorani-Lunsing, R. J., Rake, J. P., and Oudkerk, M. 1H chemical shift imaging of the brain in guanidino methyltransferase deficiency, a creatine deficiency syndrome; guanidinoacetate accumulation in the gray matter. Cochrane.Database.Syst.Rev. View abstract. 2017;14:18. Int J Sports Med 2001;22(1):76-80. Double-blind placebo-controlled study. Eur.J Appl.Physiol 2001;84(3):238-243. In fact, the only creatine monohydrate side effects ever reported are extremely mild. View abstract. View abstract. Creatine is a compound that is synthesized in your body by your pancreas and used for energy production in your skeletal muscles, with 95 percent of creatine stored in your muscles and the remaining 5 percent in your View abstract. The influence of dietary creatine supplementation on performance during repeated bouts of maximal isokinetic cycling in man. Syrotuik, D. G. and Bell, G. J. Nausea, diarrhea, etc. 2003;84(8):1206-1210. Med Sci.Sports Exerc. The effects of polyethylene glycosylated creatine supplementation on muscular strength and power. Bazzucchi, I., Felici, F., and Sacchetti, M. Effect of short-term creatine supplementation on neuromuscular function. Ziegenfuss, T. N., Rogers, M., Lowery, L., Mullins, N., Mendel, R., Antonio, J., and Lemon, P. Effect of creatine loading on anaerobic performance and skeletal muscle volume in NCAA Division I athletes. View abstract. Huso, M. E., Hampl, J. S., Johnston, C. S., and Swan, P. D. Creatine supplementation influences substrate utilization at rest. Age-related muscle loss (sarcopenia). Lancet 7-18-1998;352(9123):234. B., Gillies, E. M., and Bell, G. J. Creatine may help improve muscle strength in older adults. Kendall, K. L., Smith, A. E., Graef, J. L., Fukuda, D. H., Moon, J. R., Beck, T. W., Cramer, J. T., and Stout, J. R. Effects of four weeks of high-intensity interval training and creatine supplementation on critical power and anaerobic working capacity in college-aged men. View abstract. View abstract. Am.J.Respir.Crit.Care Med. Information from this source is evidence-based and objective, and without commercial influence. Rasmussen C, Kreider R, Ransom J, and et al. Current Therapeutic Research 1990;47(6):917-923. View abstract. Early research shows that creatine deficiency, which has been associated with this form of vision loss, can be corrected with supplements. Thorac.Cardiovasc.Surg 1992;40(1):10-13. Redondo, D. R., Dowling, E. A., Graham, B. L., Almada, A. L., and Williams, M. H. The effect of oral creatine monohydrate supplementation on running velocity. J Cardiovasc Surg (Torino) 1996;37:75-80. Odland LM, MacDougall JD, Tarnopolsky MA, et al. Kilduff, L. P., Vidakovic, P., Cooney, G., Twycross-Lewis, R., Amuna, P., Parker, M., Paul, L., and Pitsiladis, Y. P. Effects of creatine on isometric bench-press performance in resistance-trained humans. View abstract. Preen, D., Dawson, B., Goodman, C., Beilby, J., and Ching, S. Creatine supplementation: a comparison of loading and maintenance protocols on creatine uptake by human skeletal muscle. Candow, D. G., Chilibeck, P. D., Burke, D. G., Mueller, K. D., and Lewis, J. D. Effect of different frequencies of creatine supplementation on muscle size and strength in young adults. Creatine therapy in myophosphorylase deficiency (McArdle disease): a placebo-controlled crossover trial. Reduced brain creatine in gyrate atrophy of the choroid and retina with hyperornithinemia. NIH Respirology. J.Strength.Cond.Res. Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury. View abstract. It doesn't seem to help when used in lower doses, as a single dose, or when used without exercise. Gotshalk, L. A., Kraemer, W. J., Mendonca, M. A., Vingren, J. L., Kenny, A. M., Spiering, B. View abstract. J.Dev.Behav.Pediatr. Gastric acidity influences the blood response to a beta-carotene dose in humans. Despite numerous publications on the ergogenic effects of this naturally occurring substance, there is little information on the possible adverse effects of this supplement. View abstract. December 19, 1997. Med Sci.Sports Exerc. Sports Med 2015;45(9):1285-94. 2003;35(1):69-74. Int J Sport Nutr. View abstract. 2010;30(9):607-614. Anomasiri, W., Sanguanrungsirikul, S., and Saichandee, P. Low dose creatine supplementation enhances sprint phase of 400 meters swimming performance. Available at: https://www.olympic.org/fight-against-doping. Taes, Y. E., Marescau, B., De, Vriese A., De Deyn, P. P., Schepers, E., Vanholder, R., and Delanghe, J. R. Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Effects of in-season (5 weeks) creatine and pyruvate supplementation on anaerobic performance and body composition in American football players. View abstract. Med Sci Sports Exerc 2000;32:518-25. Clipboard, Search History, and several other advanced features are temporarily unavailable. Fibromyalgia. View abstract. View abstract. View abstract. Call your doctor for medical advice about side effects Trexler ET, Smith-Ryan AE, Roelofs EJ, Hirsch KR, Persky AM, Mock AG. Chambers, D. J., Braimbridge, M. V., Kosker, S., Yamada, M., Jupp, R. A., and Crowther, A. Creatine phosphate (Neoton) as an additive to St. Thomas' Hospital cardioplegic solution (Plegisol). AAPS PharmSciTech 2003;4(2):E25. Forsberg, A. M., Nilsson, E., Werneman, J., Bergstrom, J., and Hultman, E. Muscle composition in relation to age and sex. View abstract. van der Merwe, J., Brooks, N. E., and Myburgh, K. H. Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. Some evidence shows that muscle strength and fatigue seem to improve after taking creatine daily for 8-16 weeks. The Olympic Games Web site. View abstract. Recovery after surgery. Boos, C. J., White, S. H., Bland, S. A., and McAllister, P. D. Dietary supplements and military operations: caution is advised. Branch, J. D., Schwarz, W. D., and Van, Lunen B. View abstract. J Thorac.Cardiovasc.Surg. -, Med Sci Sports Exerc. View abstract. Sykut-Cegielska, J., Gradowska, W., Mercimek-Mahmutoglu, S., and Stockler-Ipsiroglu, S. Biochemical and clinical characteristics of creatine deficiency syndromes. Nutrients. View abstract. Nutrition 2011;27(4):451-455. Sports Medicine, Training and Rehabilitation. Harris RC, Soderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Pedone, V., Corbelli, C., Frondini, C., Franchi, R., Luppi, M., Lonardo, E., Balboni, A., Monetti, N., and di Biase, G. [Myocardial T1-201 scintigraphy in the study of the development of acute myocardial infarction. View abstract. View abstract. Vanakoski J, Kosunen V, Meririnne E, Seppala T. Creatine and caffeine in anaerobic and aerobic exercise: effects on physical performance and pharmacokinetic considerations. 2009;2(4):247-254. Young C, Oladipo O, Frasier S, et al. Havenetidis, K. and Bourdas, D. Creatine supplementation: effects on urinary excretion and anaerobic performance. View abstract. J Gerontol A Biol.Sci.Med Sci. View abstract. View abstract. View abstract. Amyotroph.Lateral.Scler. Med Sci Sports Exerc 1996;28(5 Suppl ):S81. View abstract. Int J Sport Nutr. View abstract. Tarnopolsky M, Martin J. Creatine monohydrate increases strength in patients with neuromuscular disease. View abstract. Stevenson, S. W. and Dudley, G. A. Dietary creatine supplementation and muscular adaptation to resistive overload. This can help improve movement and reduce seizures. J Int Soc Sports Nutr. Volek, J. S., Duncan, N. D., Mazzetti, S. A., Putukian, M., Gomez, A. L., and Kraemer, W. J. However, other research shows that taking creatine may improve lung function or exercise capacity. Nutrition 2001;17:558-66.. View abstract. Nelson, A. G., Day, R., Glickman-Weiss, E. L., Hegsted, M., Kokkonen, J., and Sampson, B. Creatine supplementation alters the response to a graded cycle ergometer test. 2002;3(1):43-46. Appl Physiol Nutr Metab. View abstract. View abstract. View abstract. J.Diet.Suppl 2010;7(3):240-252. 2010;55(3):e7-e9. Gualano B, Macedo AR, Alves CR, et al. Bernat P, Candow DG, Gryzb K, Butchart S, Schoenfeld BJ, Bruno P. Effects of high-velocity resistance training and creatine supplementation in untrained healthy aging males. Fukuda, D. H., Smith, A. E., Kendall, K. L., and Stout, J. R. The possible combinatory effects of acute consumption of caffeine, creatine, and amino acids on the improvement of anaerobic running performance in humans. Engelhardt, M., Neumann, G., Berbalk, A., and Reuter, I. Creatine supplementation in endurance sports. Buford TW, Kreider RB, Stout JR, et al. The effects of creatine supplementation on high-intensity exercise performance in elite performers. Oral creatine supplementation does not improve sprint performance in elite swimmers. 9-3-2008;95(1-2):130-134. McMorris, T., Mielcarz, G., Harris, R. C., Swain, J. P., and Howard, A. Creatine supplementation and cognitive performance in elderly individuals. Steenge, G. R., Verhoef, P., and Greenhaff, P. L. The effect of creatine and resistance training on plasma homocysteine concentration in healthy volunteers. Duke JA, Vasquez R. Amazonian Ethnobotanical Dictionary. View abstract. Tan CW, Hae Tha M, Joo Ng H. Creatine supplementation and venous thrombotic events. View abstract. Combined use of phosphocreatine and nifedipine for treatment of patients with acute myocardial infarction. Whitt, K. N., Ward, S. C., Deniz, K., Liu, L., Odin, J. Muscle Nerve 2003;27(5):604-610. Learn about potential creatine side effects. Effect of preexercise creatine ingestion on muscle performance in healthy aging males. Cochrane.Database.Syst.Rev. No effect of heavy resistance training and creatine supplementation on blood lipids. J.Cosmet.Dermatol. Inglese, M., Li, B. S., Rusinek, H., Babb, J. S., Grossman, R. I., and Gonen, O. Diffusely elevated cerebral choline and creatine in relapsing-remitting multiple sclerosis. However, creatine users have reported cramping, diarrhea, dehydration, and asthma after initiating use of the drug. View abstract. Potential Adverse Effects of Creatine Supplement on the Kidney in Athletes and Bodybuilders. Effects of 30 days of creatine ingestion in older men. 2003;38(1):44-50. Creatine supplementation during resistance training in older adults - a meta-analysis. Ayoama, R., Hiruma, E., and Sasaki, H. Effects of creatine loading on muscular strength and endurance of female softball players. View abstract. Int J Sport Nutr. View abstract. The effects of six weeks of creatine monohydrate supplementation in male and female track athletes. View abstract. Am.J.Kidney Dis. 2017 Jun;27(3):285-92. Am.J Hum.Genet. View abstract. The following doses have been studied in scientific research: View abstract. Greenhaff P. Renal dysfunction accompanying oral creatine supplements. Muscle breakdown. Int J Sports Med 1997;18:369-72.. View abstract. 2000;23(8):835-840. J Frailty Aging. J Strength.Cond.Res 2004;18(3):610-617. Green, J. M., McLester, J. R., Smith, J. E., and Mansfield, E. R. The effects of creatine supplementation on repeated upper- and lower-body Wingate performance. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. Graham AS, Hatton RC. J Appl.Physiol 2003;95(2):818-828. eCollection 2017. Lillie JW, O'Keefe M, Valinski H, et al. Ferraro S, Maddalena G, Fazio S, and et al. View abstract. J Ren Nutr. Juhn MS, Tarnopolsky M. Potential side effects of oral creatine supplementation: a critical review. But it doesn't seem to help people respond more quickly. View abstract. The CREST-E study for creatine for Huntington disease: a randomized controlled trial. Med.Sci.Sports Exerc. Mujika I, Chatard J, Lacoste L, et al. J Strength.Cond.Res 2003;17(3):439-445. Fact: There is no data that shows creatine causes muscle cramps or dehydration. Rodriguez, M. C., MacDonald, J. R., Mahoney, D. J., Parise, G., Beal, M. F., and Tarnopolsky, M. A. The effects of creatine supplementation on explosive performance and optimal individual postactivation potentiation time. View abstract. J.Inherit.Metab Dis. Neuropsychol.Dev Cogn B Aging Neuropsychol.Cogn 2007;14(5):517-528. Eur.J Appl.Physiol 2000;82(3):223-229. View abstract. View abstract. Banerjee, B., Sharma, U., Balasubramanian, K., Kalaivani, M., Kalra, V., and Jagannathan, N. R. Effect of creatine monohydrate in improving cellular energetics and muscle strength in ambulatory Duchenne muscular dystrophy patients: a randomized, placebo-controlled 31P MRS study. 2017 Prohibited List - Effective January 1, 2017. Can J Appl.Physiol 2001;26(6):527-542. Vitamin K2 and serum cholesterol in patients on continuous ambulatory peritoneal dialysis. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. J Sports Sci. 2001;33(12):2111-2117. -, Acta Physiol Scand. View abstract. View abstract. Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial. Louis, M., Lebacq, J., Poortmans, J. R., Belpaire-Dethiou, M. C., Devogelaer, J. P., Van Hecke, P., Goubel, F., and Francaux, M. Beneficial effects of creatine supplementation in dystrophic patients. Boychuk KE, Lanovaz JL, Krentz JR, Lishchynsky JT, Cando DG, Farthing JP. Mihic S, MacDonald JR, McKenzie S, and et al. View abstract. Early research shows that children with muscle loss in the spine do not benefit from taking creatine by mouth. B., Bermon, S., Andrei, S., Dalloz, E., Hebuterne, X., and Dolisi, C. Effects of oral creatine supplementation on maximal pedalling performance in older adults. Greenhaff, P. L. Creatine and its application as an ergogenic aid. Schulze, A., Hess, T., Wevers, R., Mayatepek, E., Bachert, P., Marescau, B., Knopp, M. V., De Deyn, P. P., Bremer, H. J., and Rating, D. Creatine deficiency syndrome caused by guanidinoacetate methyltransferase deficiency: diagnostic tools for a new inborn error of metabolism. View abstract. Finn, J. P., Ebert, T. R., Withers, R. T., Carey, M. F., Mackay, M., Phillips, J. W., and Febbraio, M. A. 2009;108(3):711-713. Isbrandt, D. and von Figura, K. Cloning and sequence analysis of human guanidinoacetate N-methyltransferase cDNA. Int.J.Sports Physiol Perform. J Spinal Cord.Med 2005;28(3):208-213. Am Heart J 1988;116(2 Pt 1):393-397. However, some people may experience slight stomach and digestive discomfort like gas or bloating or possibly diarrhea for a few weeks when first starting the use of creatine. Wadman, R. I., Bosboom, W. M., van den Berg, L. H., Wokke, J. H., Iannaccone, S. T., and Vrancken, A. F. Drug treatment for spinal muscular atrophy types II and III. Cochrane Database.Syst.Rev. Chrusch, M. J., Chilibeck, P. D., Chad, K. E., Davison, K. S., and Burke, D. G. Creatine supplementation combined with resistance training in older men. Eur J Neurol 2005;12(4):300-309. Kern M, Podewils LJ Vukovich M Buono MJ. Drory, V. E. and Gross, D. No effect of creatine on respiratory distress in amyotrophic lateral sclerosis. Van Bavel D, de Moraes R, Tibirica E. Effects of dietary supplementation with creatine on homocysteinemia and systemic microvascular endothelial function in individuals adhering to vegan diets. View abstract. Bosboom, W., Vrancken, A. F., van den Berg, L. H., Wokke, J. H., and Iannaccone, S. T. Drug treatment for spinal muscular atrophy types II and III. So before you go all-in on taking creatine, here's what the supplement actually is, what it does, and how to avoid any of its side effects. The influence of recovery duration on high-intensity exercise performance after oral creatine supplementation. Effect of creatine feeding on maximal exercise performance in vegetarians. Int J Sports Med 2001;22(8):546-552. O'Rourke, D. J., Ryan, S., Salomons, G., Jakobs, C., Monavari, A., and King, M. D. Guanidinoacetate methyltransferase (GAMT) deficiency: late onset of movement disorder and preserved expressive language. 2009;19(5):399-404. NINDS NET-PD Investigators. Creatine Monohydrate Side Effects As far as what we've experienced, the best part about creatine is that there are no adverse side effects of creatine. Diabetes 2001;50(1):18-23. Int J Sport Nutr. 1999;9(2):136-145. Early research shows that taking creatine twice daily for 12-18 months slows the progression of Parkinson disease in people who have not yet started conventional medicines. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Early research shows that taking creatine by mouth before hemodialysis treatments seems to reduce muscle cramps. Cochrane.Database.Syst.Rev. Pfeffer, G., Majamaa, K., Turnbull, D. M., Thorburn, D., and Chinnery, P. F. Treatment for mitochondrial disorders. Mercimek-Mahmutoglu, S., Connolly, M. B., Poskitt, K. J., Horvath, G. A., Lowry, N., Salomons, G. S., Casey, B., Sinclair, G., Davis, C., Jakobs, C., and Stockler-Ipsiroglu, S. Treatment of intractable epilepsy in a female with SLC6A8 deficiency. 2016 Mar 4;8(3):143. View abstract. Rico-Sanz J, Mendez Marco MT. 2016 May;30(5):1438-46. Cholestatic jaundice as a result of combination designer supplement ingestion. Chilibeck, P. D., Stride, D., Farthing, J. P., and Burke, D. G. Effect of creatine ingestion after exercise on muscle thickness in males and females. View abstract. Nat Med 1999;5:347-50. View abstract. Early research also shows that taking creatine by mouth daily for 6 months reduces amnesia following a traumatic brain injury in children. 1997;131(4):626-631. Koenig CA, Benardot D Cody M Thompson WR. Med Sci Sports Exerc 1999;31:1108-10. Early research shows that taking creatine by mouth does not improve muscle function or quality of life in people with mitochondrial myopathies. Potential benefits of creatine monohydrate supplementation in the elderly. Creatine isn't recommended for people with kidney or liver disease, or diabetes . View abstract. Matthews RT, Ferrante RJ, Klivenyi P, et al. View abstract. Single- and multiple-dose pharmacokinetics of oral creatine. View abstract. View abstract. View abstract. Can You Prevent Dyskinesia in Parkinson's? Snow RJ, McKenna MJ, Selig SE, et al. Physiological response to exercise in the heat following creatine supplementation. NINDS NET-PD Investigators. 1993 Dec;149(4):521-3 Med Sci Sports Exerc 2000;32:706-17. This article examines the necessity, benefits and side effects of the creatine loading phase. Ostojic SM, Stajer V, Vranes M, Ostojic J. Searching for a better formulation to enhance muscle bioenergetics: A randomized controlled trial of creatine nitrate plus creatinine vs. creatine nitrate vs. creatine monohydrate in healthy men. Arch Neurol 2000;57:956-63. Acute creatine ingestion in human: consequences on serum creatine and creatinine concentrations. Neves, M., Jr., Gualano, B., Roschel, H., Lima, F. R., Lucia, de Sa-Pinto, Seguro, A. C., Shimizu, M. H., Sapienza, M. T., Fuller, R., Lancha, A. H., Jr., and Bonfa, E. Effect of creatine supplementation on measured glomerular filtration rate in postmenopausal women. Wilder, N., Gilders, R., Hagerman, F., and Deivert, R. G. The effects of a 10-week, periodized, off-season resistance-training program and creatine supplementation among collegiate football players. But taking creatine does not seem to improve brain creatine levels, movement, or mental function in children who have a disorder in which creatine isn't transported properly. 2002;17(11):1978-1981. Hibbard MK, Sandri-Goldin, RM. Cisowski M, Bochenek A, Kucewicz E, et al. Lack of efficacy of 5 grams daily of creatine in schizophrenia: a randomized, double-blind, placebo-controlled trial. Heat intolerance 10. However, other research shows that creatine provides no benefit for people with muscular dystrophy. Sports Med 1994;18:268-80. View abstract. View abstract. Reuters Health 2000;Jun 13. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. 1-18-1995;134(2):53-56. Effects of creatine monohydrate supplementation during combined strength and high intensity rowing training on performance. Clin Sports Med 1998;17:283-97. View abstract. de Guingand DL, Palmer KR, Snow RJ, Davies-Tuck ML, Ellery SJ. Early studies show that taking creatine might produce small improvements in muscle strength in people with these conditions. Amino.Acids 2012;43(4):1803-1807. View abstract. J Sports Sci 2010;28(1):67-74. 2001;33(10):1667-1673. Arch Neurol 2002;59(1):97-101. Herda, T. J., Beck, T. W., Ryan, E. D., Smith, A. E., Walter, A. Creating supplementation and lower limb strength performance: a systematic review and meta-analysis. Clin J Sport Med 1998;8(4):286-297. Lancet 1998;351:1252-3. 2008;7(1):15-22. View abstract. Nutrients. However, analyses of this research show that creatine seems to modestly improve upper body strength and lower body strength in both younger and older adults. , studies have shown that consumption of creatine in resting and exercised muscle of normal subjects by creatine supplementation health..., Curtis S, Roschel H, gualano B, Stucki G, S. Med 2017 ; 47 ( 7-8 ): e303-e307 of high doses creatine... 59 ( 1 ):41-43 retention during creatine loading on long-term sprint exercise performance in competitive swimmers 51 ( Suppl! Phys Fitness 2002 ; 93 ( 6 ):1780. doi: 10.1007/s00726-011-0878-2 men ( abstract ) J Appl Occup! Weakness ( idiopathic inflammatory myopathies ) ( I ) accumulation during creatine supplementation, Vincent, W. D. Gutmann! 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